The Hippocratic Crush II (AKA On Call 36 Hours II) immediately follows off from The Hippocratic Crush (AKA On Call 36 Hours), following the lives of doctors, new and old, facing the patients and challenges that unfold before them. Cheung Yat Kin/Yat Kin Tau (Kenneth Ma) and Fan Chi Yu/Yu Jai (Tavia Yeung) are now happily married to each other but life ahead is not easy for them. They are faced with new obstacles that they have to face together if they are to keep their relationship growing strong. Chi Yu finds herself pregnant but being diagnosed with intramedullary spinal cord tumour makes her unfit to continue with the pregnancy. However, she insists on carrying on with the pregnancy and this causes numerous disputes between the couple. Though this does not mean that Yat Kin loves Yu Jai any less; he just canâ€™t bear watching her suffer so he offers to carry some of her burden. The challenges that he has to face with Yu Jai on top of his stubborn personality takes a toll on his relationship with newly transferred pathology specialist, Lok Man San/Lokman (Lawrence Ng). The two are constantly at each otherâ€™s head with differing opinions and their different approach with medicine further causes tension between the two doctors. Lokman gets involved with fellow internal medicine doctor, Heung Chin Yi (Tracy Chu), who is twenty years his junior. Lokman and Chin Yi have a very different view towards love. Lokman is a widowed man with a young daughter while Chin Yi is left having to take care of her runaway boyfriendâ€™s son. Through mutual understanding and hardships, the two grow to love each other despite their age difference. Yu Jaiâ€™s diagnosis causes her to suffer a miscarriage as well as making her incompetent to perform surgery on patients. This is a huge blow to her as well as Yat Kin Tau. His mother also falls sick and this added on to all the pressure in life causes him to develop an anxiety disorder. However, with Yat Kin Tau by her side, Yu Jai isnâ€™t ready to give up yet; she wants to help Yat Kin Tau to stand strong again. So she decides to switch afresh, switching from cardiology to pathology, learning under the disciplinary of Lokman who helps her to regain her strength. Meanwhile, Yu Jaiâ€™s sister and neurosurgeon, Hong Mei Seut (Mandy Wong) also has her own challenges to face as she finally becomes a doctor in in her own right. However, that is not the only challenge in her life. Her relationship with orthopaedic surgeon boyfriend Lau Ping Chan/Benjamin (Benjamin Yuen) heads on the rocks as their relationship turns into a love triangle. Fresh neurosurgeon, Yeung Pui Chung (Him Law) undergoes his own journey to become a better doctor. As his career picks up, he finds himself in a love triangle with training doctor, Zung Zi Ting (Crystal Li) and social worker, Ce Hui Tung (Eliza Sum) who suffers from a chronic illness. Yat Kin Tau finds it difficult to accept the new challenges in his life, however, as he watches his friends and fellow subordinates, Mei Seut and Pui Chung grow to become independent, capable and experienced doctors, he learns that he must first protect himself before he can protect others. Will he be able to do this and protect those whom he loves and cares about? What is the true meaning behind being a doctor? It is merely about saving about patients? What about the doctors themselves?