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GO CHI JUICE
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The World's Most Powerful Anti-Aging Food



Did you know that in some remote places in this world, a life expectancy of more than 100 years is not uncommon?

Research has shown that many of the world's longest living people consume regular daily helpings of a tiny red fruit that may just be the world's most powerful anti-aging food: the goji berry.

FreeLife® is the first company to perfect a difficult and demanding proprietary extraction process and create the only standardized form of this incredible plant available in the world today: The Science Team



At FreeLife, we are committed to being the driving force for international goji research to continue to unlock goji’s secrets for the betterment of mankind. FreeLife’s Science Team members include Executive officers of FreeLife and the Scientific Advisory Board. The Scientific Advisory Board members are independent scientists who are leading experts in the fields of nutrition and health and act in an advisory capacity with FreeLife.



FreeLife Science Team - Click Each Member To Learn More



Haru Amagase, Ph.D.
Chief Scientific Officer

Rick Handel
Chief Product Officer



Scientific Advisory Board



Carmia Borek, Ph.D.
Tufts University

Julie Hazel Campbell, Ph.D., AO, FAA
University of Queensland

Norman R. Farnsworth, Ph.D.
University of Illinois at Chicago

Dwight M. Nance, Ph.D.
University of California, Irvine

Vivienne Elizabeth Reeve, Ph.D.
The University of Sydney

Richard S. Rivlin, M.D.
Weill Cornell Medical College
GoChi™ Science



The GoChi Effect™

Fight the Effects of Modern Society with Age-Old Wisdom

In three recent randomized, double-blind, placebo-controlled, human clinical trials, GoChi™ proved extremely effective for human health in 19 key areas. In the initial groundbreaking study, which has been accepted for publication by the highly respected Journal of Alternative and Complementary Medicine, participants drinking just 4 ounces daily saw positive results in multiple categories of health and well-being in as little as 14 days! Two subsequent studies showed that drinking 4 ounces of GoChi on a daily basis significantly improved the body’s immune system and antioxidant capacity within just 30 days! The 19 benefits identified in FreeLife’s three GoChi studies are no coincidence. They are all interrelated, and have been collectively termed The GoChi Effect™. GoChi™ Science

January 2008

A Randomized, Double-blind, Placebo-controlled, Clinical Study of the General Effects of a Standardized Lycium barbarum (Goji) Juice, GoChi™







BACKGROUND

For thousands of years, the goji berry (Lycium barbarum) has been a mainstay of Traditional Chinese Medicine (TCM), and its remarkable and diverse health-promoting properties have earned it a reputation as Asia’s most potent health food. But outside of its native continent, the goji berry was virtually unknown until FreeLife International® introduced the Asian health secret to the world with the 2003 launch of Himalayan Goji® Juice. Since that time, goji has attracted increasing media attention as an anti-aging superfruit, and it has become a favorite of celebrities, world-class athletes, and health-savvy consumers worldwide.

The global goji phenomenon has aroused much scientific interest as well, and there are now dozens of published research papers that offer scientific validation of the berry’s legendary attributes. Science has also revealed that the goji berry’s broad-based health benefits are due primarily to the presence of unique molecules, not found in any other fruit, called Lycium barbarum polysaccharides (LBP). Unlike dried berries or any other goji product, Himalayan Goji Juice is standardized to a consistently high level of the all-important LBP.

REASONS FOR THE STUDY

Since its launch, users of Himalayan Goji Juice have reported dramatic and rapid improvements in energy levels, quality of sleep, feelings of calmness and contentment, reduction of stress, and other key health aspects. It was proposed that these rapid and noticeable improvements might be attributable to the juice’s high degree of LBP standardization and high absorption potential, and to support this, a study was designed to attempt to demonstrate these same dramatic results under rigorous and tightly controlled clinical conditions. For this study, FreeLife® selected GoChi™, the next generation of Himalayan Goji Juice. The result of several years of scientific development, GoChi is an enhanced Himalayan Goji Juice formula containing at least 30% more bioactive LBP than the original formula. GoChi is also preservative-free, is certified both kosher and halal, and has 20% fewer calories and an even better taste than the original formula.

STUDY DESIGN

The duration, sample population, and methods of this randomized, double-blind, and placebo-controlled study conformed to the norms of FDA Good Clinical Practice. In this 14-day clinical trial, 35 healthy adult subjects were divided into two groups selected at random to ensure fair and even distribution of health status between the two groups. After a two-week washout period for all subjects, the GoChi group was administered a 120 ml (4 fl. oz.) daily dose of a goji juice (GoChi) containing a standardized content of Lycium barbarum polysaccharides (LBP), the acknowledged bioactive principles of the goji berry. The second, or placebo group, received a 120 ml (4 fl. oz.) daily dose of a placebo control solution that tasted, smelled, and looked like GoChi, but did not contain any goji juice or LBP. The participants had no knowledge as to whether they were drinking the GoChi or the placebo, and the scientists also had no knowledge as to which group was receiving the GoChi or the placebo. The GoChi group consisted initially of 17 individuals, of which 16 completed the study. The placebo group consisted of 18 individuals.

Based upon the properties of Lycium barbarum in TCM and the health benefits reported by FreeLife customers, the participants were examined by questionnaire for subjective ratings (0-5) of general feelings of well-being, neurological/psychological traits, gastrointestinal, musculoskeletal and cardiovascular complaints, as well as any adverse effects. Data were statistically analyzed for changes between day 1 and day 15. Descriptive statistics were calculated for placebo and GoChi for all dependent measures and summarized as means and standard errors. For all clinical symptom questions under all categories, each question was graded and the scores analyzed for changes between day 1 and day 15 with the nonparametric Wilcoxon matched pairs tests.

RESULTS

The GoChi group showed statistically significant improvements (confidence level at 90-99%) between day 1 and day 15 in the following 13 key health aspects: increased energy, less fatigue, increased focus and mental acuity, improved athletic performance, reduced stress, increased feelings of calmness and contentment, feeling happier, healthier and more regular, better quality of sleep, and easier ability to awaken in the morning. In addition, over 90% of those who consumed GoChi reported feeling an improvement in their health.

In contrast to the GoChi group, the placebo group only showed a statistically significant improvement in 1 of the 13 categories (happiness). No statistically significant changes were found in any of the other 12 categories. There were no adverse events reported by any subjects in either the GoChi or the placebo group during the study period.

CONCLUSION

The results shown in this randomized, placebo-controlled, double-blind, clinical study clearly indicate that daily consumption of GoChi can cause immediate and significant improvement in 13 aspects of general well-being, neurological/psychological traits, and gastrointestinal function. These reported benefits are consistent with previously published experimental studies, with the prescribed uses of Lycium barbarum as practiced in Traditional Chinese Medicine, and with the benefits reported by FreeLife customers the world over.
GoChi™ Science

April 2008

A Randomized, Double-blind, Placebo-controlled, Clinical Study of the in vivo Antioxidant Effects of a Standardized Lycium barbarum (Goji) Juice, GoChi™







BACKGROUND

For thousands of years, the goji berry (Lycium barbarum) has been a mainstay of Traditional Chinese Medicine (TCM), and its remarkable and diverse health-promoting properties have earned it a reputation as Asia’s most potent health food. Goji’s ancient tradition is now being confirmed by modern science, and dozens of published research papers have revealed that the goji berry’s broad-based health benefits are due primarily to the presence of unique molecules, not found in any other fruit, called Lycium barbarum polysaccharides (LBP). Unlike dried berries or any other goji product, FreeLife’s GoChi™ is standardized to an unprecedented potency of the all-important LBP.

In a recent clinical study, which was accepted for publication in the peer-reviewed Journal of Alternative and Complementary Medicine, participants who used GoChi experienced significant improvement in 13 key aspects of health and well-being in just 14 days.* The new antioxidant study discussed herein is yet another demonstration of the remarkable power of GoChi, and it illustrates FreeLife’s ongoing commitment to lead the nutrition industry in clinical research, product efficacy, and evidence-based product formulation.

REASONS FOR THE STUDY

Antioxidants play an important role in preventing damage to the body caused by harmful environmental oxygen free radicals. Although ordinary oxygen (O2) is necessary for life, its free radical forms are unstable and can attack healthy cells, causing premature aging and contributing to disease. For this reason, many people seek to increase their intake of dietary antioxidants, especially foods and beverages with high scores on a laboratory test called ORAC (Oxygen Radical Absorbance Capacity). But ORAC only measures antioxidant potential in a test tube and does not take into account the complexities of the human body. Many food antioxidants, particularly those found in fruits and fruit juices, are not well-absorbed and so they become trapped in the digestive tract. The poor bioavailability of fruit antioxidants has been well-documented in important research papers.(1,2)

It is far more meaningful to human health to maintain high serum levels of the body’s own (endogenous) antioxidants, namely superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). These vital antioxidant enzymes circulate in the blood throughout the entire body to neutralize all types of free radicals before they can do harm. The enzymes have other important functions as well: SOD plays a key role in the body’s inflammation responses, and glutathione enzymes like GSH-Px are necessary for many detoxification processes. Both enzymes are especially effective at reducing lipid peroxidation, a particularly dangerous form of free-radical damage that is associated with increased health risk. In blood tests, lipid peroxidation is indicated by the presence of the toxic body chemical malondialdehyde (MDA).

Prior third-party research studies in cell culture and in animals have suggested that goji’s bioactive LBP might improve antioxidant protection by reducing MDA and increasing SOD and GSH-Px. This study is the first controlled human clinical trial to attempt to demonstrate an actual in vivo increase in antioxidant power and a corresponding decrease in harmful free-radical activity.

1 Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79: 727-47
2 Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130(8): 2073S-2085S

STUDY DESIGN

This randomized, double-blind, and placebo-controlled 30-day clinical trial was conducted at a prestigious independent research institute in Asia and was designed to conform to the spirit of US FDA Good Clinical Practice. Fifty healthy adult subjects were divided into two groups selected at random to ensure fair and even distribution of health status between the two groups. The GoChi group was administered 120 ml (4 fl. oz.) daily of GoChi. The placebo group received the same daily dosing of an inactive placebo, a control solution that tasted, smelled, and looked like GoChi, but did not contain any goji juice or LBP. Neither the participants nor the scientists had any knowledge as to which group was drinking the GoChi and which was drinking the placebo. Furthermore, the participants and scientists had no affiliation with FreeLife®, and had no familiarity with GoChi or Himalayan Goji® Juice prior to the start of the study.

Before beginning the study, all participants were tested for serum levels of SOD, GSH-Px, and MDA. There were no significant differences in starting point levels between the two groups, thus confirming suitability and compatibility. After the 30-day duration of the trial, serum analysis was performed once again in each group to determine statistically if there were any significant changes in serum SOD, GSH-Px, and MDA between the start of the study and its completion.

RESULTS

The GoChi group showed highly significant (p<0.01) improvements in serum levels of both endogenous antioxidant enzymes. SOD was increased by 8.39% over the starting point, and GSH-Px was increased by 9.87%. Along with the increased antioxidant activity observed in this study, there was a corresponding reduction in MDA, a prime indicator of free-radical damage and a known health risk factor. MDA levels were improved significantly (p<0.05) in the GoChi group, decreasing 8.66% during the course of the study. No statistically significant changes were found in the placebo group for any of the three serum markers tested. There were no adverse events reported by any subjects in either the GoChi or the placebo group during the study period.

Unlike the GoChi group, the placebo group experienced no meaningful change in immune status. When compared to the placebo group, the GoChi group also experienced far greater and statistically significant (p<0.05) improvement in well-being, with a 63% total improvement in areas such as reduced fatigue and improved sleep quality, and with a tendency toward improved short-term memory and mental focus over the trial period. These findings were consistent with those shown in previous GoChi studies.

CONCLUSION

The results shown in this randomized, double-blind, placebo-controlled clinical study clearly indicate that daily consumption of GoChi for 30 days can significantly improve three key aspects of healthy