Jintropin rhGH
GeneScience Pharmaceuticals Co, Ltd.
Dear Customers here is our product information along with pricing.
Please email us for shipping and payment information at
genescience@hushmail.com, along with any specific questions.
We normally ship orders by UPS, DHL or TNT. If you decide to order
with 100% guarantee delivery insurance, the total price (with
shipping included);
Jintropin Kits
1 x 100iu kit = $400.00
5 x 100iu kit = $1,875.00
10 x 100iu kit = $3,500.00
We accept payment by e-bullion this is prefered as it's more
convenient, faster and easier to keep track of your orders and the
shipment can be mailed out the next day.
JINTROPIN
1. NAME OF THE MEDICINAL PRODUCT JINTROPIN (Recombinant human
growth hormone (rDNA origin) for injection). Powder for injection
I0 IU.
2. QUALITATIVE AND QUANTITATIVE COMPOSITION OF ACTIVE INGREDIENT
Powder for injection substance I0 IU. One vial contains Powder for
injection of (rDNA origin) I0 IU.
3. PHARMACEUTICAL FORM Powder for injection prepared with supplied
solvent, with out preservative for subcutaneous (s. c.)
administration.
4. PHARMACO-THERAPEUTIC GROUP Human Growth Hormone. HGH (rDNA
origin). JINTROPIN stimulates linear growth and increases growth
rate in children who lack adequate endogenous growth hormone. In
adults with growth hormone deficiency. JINTROPIN reduces fat mass,
increases muscle mass and improves energy also vitality and
subjective well being. In patients suffering from severe burns,
AIDS associated muscle wasting, or undergoing major operations.
JINTROPIN promotes wound healing, attenuates the protein-catabolic
response and improves whole- body nitrogen condition after
operation.
5. HOLDER OF THE AUTHORIZATION JINTROPIN is manufactured by
GeneScience Pharmaceuticals Co. LTD, in Changchun, China. It is the
largest biotech company in China and further information can be
obtained from the local GeneScience offices in the different Member
States.
6. THERAPEUTIC INDICATIONS Growth disturbance due to insufficient
secretion of growth hormone or associated with gonadal dysgenesis
or Turner's syndrome, which is a chromosome aberration. Growth
disturbance in children with chronic renal insufficiency.
Replacement therapy in adults with pronounced growth hormone
deficiency. Promote wound healing and attenuate catabolic responses
in severe burns, sepsis, multiple trauma, major operations, acute
pancreatitis and intestinal fistula. Topical application to promote
wound healing in acute wound or chronic ulcer, such as burns,
diabetic foot ulcer, chronic venous ulcer and decubital ulcer.
7. CONTRAINDICATIONS JINTROPIN should not be used when there is any
evidence of activity of brain tumor. Intracranial lesious must be
inactive and antitumour therapy completed prior to starting
therapy. JINTROPIN should not be used for growth promotion in
children with closed epiphyses.
8. WARNINGS AND PRECAUTIONS The diagnosis should be confirmed
before treatment starts. Therapy with Jintropin should be directed
by suitably qualified physicians. In diabetes mellitus the dose of
insulin might require adjustment by your physician before JINTROPIN
treatment starts. Experience in adult GHD patients above 60 years
is lacking. Experience with prolonged treatment in adults is
limited. In chronic renal insufficiency the renal function should
be investigated before start of the treatment. The treatment should
be discontinued after renal transplantation.
9. INTERACTIONS WITH OTHER MEDICAMENTS AND OTHER FORMS OF
INTERACTION See under 10. PREGNANCY AND LACTATION
10. NO CLINICAL EXPERIENCE OF THE USE IN PREGUANT WOMEN IS
AVAILABLE. Treatment with JINTROPIN should be interrupted if
pregnancy occurs. Information is lacking whether peptide hormones
pass over into the breast milk but absorption in the gastro -
intestinal tract of the infant of intact protein is extremely
unlikely.
11. EFFECTS ON ABILITY TO DRIVE AND USE MACHINES The ability to
react is not influenced by JINTROPIN.
12. DOSAGE AND ADMINISTRATION The dosage is based on the
individual’s body weight or body surface area and should be
determined by your physician. Growth disturbance due to
insufficient secretion of growth hormone in children: Generally a
dose of 0.5 - O. 7 IU/kg/wk or 14-20 IU/m2/wk is recommended. Even
higher doses have been used. Gonadal dysgeuesis (Turner's
syndrome): A dose of 1.0 IU/kg/wk or 28 IU/m2/wk is recommended.
Chronic renal insufficiency: A dose of 30 IU/m2/wk (approximately
1.01U/kg/wk) is recommended. Higher doses can be needed if growth
velocity is too slow. A dose correction can be needed after six
months of treatment. Growth hormone deficiency in adults: An
initial dose for about four weeks of 0.125 IU/kg/wk, is
recommended. The daily dose should then be modulated according to
the side effects of the patients as well as determination of
lnsulin like Growth Factor-l (lGF - I) in serum as guidance. The
weekly dose should be divided into 7 s. c. injections. The
injection site should be varied to prevent lipoathrophy. If
treatment has been forgotten one day do not take double doses the
next day but continue the treatment according to the directions.
For severe burns or multiple injuries, it is recommended an initial
dose of 10IU/day followed by 16IlU/day after patients' blood
glucose level is stabilized. Typical treatment starts in 6 days
after burns or injuries and treatment length is about 15-20 days.
For major operations, 1O IU/day for a period of 10 days is
recommended. Typical treatment starts in 2 - 3 days after
operations. For topical application to wound or ulcer surface, a
dose of 0.2 IU/cm2 is recommended at three times a day. Length of
treatment depends on healing time.
13. OVERDOSAGE No overdose or intoxication is known. If an overdose
of JINTROPIN has been injected contact should be taken with your
physician.
14. ADVERSE REACTIONS Side effects have been noted in approximately
10%, (most common local skin reactions) of the patients
participating in clinical trials in children with short stature. In
clinical trials in adults side effects have been noted in
approximately 30 to 40% of the patients, primarily related to
symptoms of fluid retention (oedema). These events have an early
onset after initiation of therapy, but with a reduction in
incidence and prevalence over time and rarely influencing daily
activities. JINTROPIN has given rise to the formation of antibodies
in very few patients. This has no influence on the treatment
result. It has been reported that patients may develop
hypothyroidism during treatment with JINTROPIN, which should be
considered by your physician. If nausea and/or vomiting, severe and
recurrent headache especially in combination with visual problems
occur take contact with your physician.
15. INCOMPATIBILITIES Incompatibilities have not been reported for
combined use of JINTROPIN with other medicaments or medical
solution.
16. SHELF LIFE The powder for injection is assigned a shelf life of
24 months when stored cold at + 2 - +8 ' C. Storage for seven days
can take place in room temperature. Reconstituted JINTROPIN with
preservative may be stored cold at +2- +8' C for 2 weeks protected
from light.
17. SPECIAL PRECAUTIONS FOR STORAGE Frozen powder should not be
used. Store cold at 1+2- + 8'C.
18. INSTRUCTIONS FOR USE/HANDLING Vials: add solvent to vial with
powder for injection. Gently dissolve the drug with a slow,
swirling motion. Do not shake vigorously, or the active ingredient
might denature.
Comments
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