A mysterious object plummets to Earth, sending out a shock wave that causes five strangers to die, only to miraculously come back to life moments later. The members of the group are Vera (Shantel VanSanten), a struggling radio-astronomer living in New Mexico who is searching for her missing son; Erin (Sofia Black-D'Elia), a young mother in Tucson, Arizona who is desperate to protect her seven-year-old daughter Amy from her abusive policeman ex-husband; Peter (Joel Courtney), a troubled high school student and orphan in Little Rock, Arkansas; Raul (J.D. Pardo), a federal agent in Mexico who is looking to escape his dangerous and violent undercover assignment; and Joshua (Jon Fletcher), a charismatic second-generation televangelist in Houston, Texas. Most mysterious of all is the figure known only as The Man (Diogo Morgado), who offers Vera the location of her abducted son if she will help him with one morally complicated task which puts her on a collision course with Rose (Anna Diop), a nurse in Houston who has been in a coma for seven years after being shot by an unknown hitman. Drawn together by fate and biblical prophecy, "The Messengers" soon learn they now have supernatural gifts that might be the only hope for preventing the impending Rapture.