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Tabex® is an effective product for treatment of nicotine dependence in case of serious desire for smoking cessation.


Tabex®is an original Bulgarian product, trademark of Sopharma JSCo. Cytisine is the active substance of the medicinal product – an alkaloid contained in the plant leguminous tree (Cytisus laburnum L.). Cytisine has structure and mechanism of action similar to those of nicotine and decreases its period of interaction with the specific receptors. Thus, it prevents the appearance of abstinence syndrome. The result is gradual decrease of the typical smokers’ psychic and physical nicotine dependence and subsequent smoking cessation without undesirable effects.

One film-coated tablet Tabex contains 1.5 mg cytisine.

Tabex has an excellent safety profile:
•Tabex® has very good tolerance and in therapeutic doses it does not cause anorexia, nausea and vomiting.
•It does not affect the active drivers’ attention and machine operating
•It is not recommended only in high level hypertension, advanced atherosclerosis, pregnancy and breast-feeding

Tabex is a medicinal product against smoking that contains cytisine.

Tabex®has a comprehensive effect on pathogenetic mechanisms of nicotine dependence:
•The alkaloid cytisine is a powerful antagonist of nicotine receptors
•Cytisine has wider therapeutic range than nicotine which makes its profile of action safer.
•Cytisine reduces depressive symptoms related to discontinuation of nicotine intoxication
•Compared to nicotine, it has much weaker effect on the peripheral nervous system and blood pressure
Days 1 to 3 – 1 tablet every 2 hours or 6 tablets daily
Days 4 to 12 – 1 tablet every 2,5 hour or 5 tablets daily
Days 13 to 16 – 1 tablet every 3 hour or 4 tablets daily
Days 17 to 20 – 1 tablet every 4 hours or 4 tablets daily
Days 18 to 25 – 1 tablet every 6 hours or 2 tablets daily

Precautions: smoking causes unpleasant feeling during Tabex® administration. The quantity of cigarettes smoked during the first three days should be decreased. Total smoking cessation should occur not later than the fifth day after the beginning of the course.

The course of treatment usually lasts 25-30 days.
TABEX® is an original Bulgarian herbal medicinal product of plant origin

In the distant 1865 acad. А. Orehov found out and chemically analysed the alkaloid cytisine contained in Family Papilionaceae and is the main active substance of TABEX®. Cytisine belongs to the group of nicotine blockers that are known in clinical practice as respiration stimulators. The pharmacological study of cytisine at the Pharmacology Department of the Sofia Medical Institute started as early as in the 50s of the last century and their aim was to create an ampoule dosage form for the needs of resuscitation. During experimental studies on anaesthetised cats, two famous Bulgarian pharmacologists – Prof. Paskov and Dr. Dobrev reached to the important conclusion that due to its lower toxicity than nicotine and mostly to its weaker peripheral effect on the cardiovascular system, cytisine can be used as a smoking cessation device, as it interacts with the same receptors in human body together with nicotine.

The intriguing thing in that story is that half a century ago two heavy smokers-pharmacologists arrived at the good idea how to give an opportunity to the cigarettes-dependent individuals to go through the abstinence syndrome easily (a condition of bad mood, anxiety, headache, etc.), accompanying the cigarette quitting period and at the same time to feel stimulated, as cytisine also has confirmed anti-depressive effect.

In 1962 in Bulgaria Prof. Isaev isolated cytisine from the golden chain plant and started an intensive research on the creation of the original medicinal product TABEX®. Large clinical trials in Bulgaria, Germany and Poland followed that confirmed the efficacy and most of all the need of positive attitude in smoking cessation attempts.

It is well known that depressive moods and abstinence syndrome are psychic conditions, that accompany any dependency, that are most difficult to overcome. The extensive clinical research conducted in Bulgaria and abroad confirmed this advantage of TABEX® - trademark of Sopharma.