Item Information
Estimated Shipping 10 - 15 Days
Item Description
Quadriderm Cream 15 gr(0.53oz)
Brand names: Quadriderm Cream
Generic name: Betamethasone
Manufacturer: Schering-Plough
Quadriderm Cream
For Dermatological use only

Description:
Each gram of Quadriderm Cream contains:
Betamethasone (as valerate) 0.5 mg (0.05%)
Gentamicin (as sulfate) 1 mg (0.1% )
Tolnaftate 10 mg (1.0%)
Clioquinol 10 mg (1.0%)
In a paraben and lanolin free water washable cream base containing 0.1% chlorocresol as a preservative.
Inactive ingredients: chlorocresol, ceteth 20, cetostearyl alcohol, white petrolatum, mineral oil and
sodium phosphate monobasic monohydrate.

ACTIONS:
Quadriderm Cream combines the anti-inflammatory, anti-pruritic and vasoconstrictive agent betamethasone valerate, the wide spectrum antibiotic gentamicin sulfate, the fungicidal agent tolnaftate and clioquinol, an antibacterial and antifungal agent.

INDICATIONS:
Quadriderm Cream is indicated for the relief of the inflammatory manifestations of corticosteroid-responsive dermatoses when complicated by secondary infection caused by organisms sensitive to the components of this dermatologic preparation. Such disorders include inguinal dermatosis, eczematoid dermatitis, contact dermatitis, microbial, dermatitis, follicular dermatitis, parakeratosis, anal pruritus, seborrheic eczema, intertrigo, seborrheic dermatitis, impetigo, zona occipital, lichenified inguinal dermatophytosis and tinea infections such as tinea pedis, tinea cruris and tinea corporis

DOSAGE AND ADMINISTRATION:
A thin film of Quadriderm Cream should be applied to cover completely the affected area two or three times daily, or as prescribed by the physician. Frequency of application should be determined according to severity of the condition.
Duration of therapy should be determined by patient response. In cases of tinea pedis longer therapy (2-4 weeks) may be necessary.

ADVERSE REACTIONS:
Local adverse reactions reported with the use of topical corticosteroids, especially, under occlusive dressings, include: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae and miliaria.
Rash, irritation and hypersensitivity have been reported with the topical usage of gentamicin sulfate, clioquinol and rarely with tolnaftate.

CONTRAINDICATIONS:
Quadriderm Cream is contraindicated in those patients with a history of sensitivity reactions to any of its components.

PRECAUTIONS:
Any of the side effects that are reported following systemic use of corticosteroids, including adrenal suppression, may also occur with topical corticosteroids, especially in infants and children.
Systemic absorption of topical steroids will be increased if extensive body surface areas are treated or if the occlusive technique is used. Suitable precautions should be taken under these conditions or when long-term use is anticipated, particularly in infants and children.
Systemic absorption of topically applied gentamicin may be increased if extensive body surface area are treated, especially over prolonged time periods or in the presence of dermal disruption. In these cases, the undesirable effects which occur following systemic use of gentamicin may potentially occur. Caution use is recommended under these conditions, particularly in infants and children.
Prolonged use of topical antibiotics occasionally may result in overgrowth of non-susceptable organisms. If this occurs, or if irritation, sensitization or superinfection develops, treatment with Quadriderm Cream should be discontinued and appropriate therapy instituted.
Systemic absorption of clioquinol may interfere with thyroid function tests.
The ferric chloride test for phenylketonuria can yield a false-positive result if clioquinol is present in the urine. Slight staining of linens or clothing due to clioquinol may occur.
Quadriderm cream is not for ophthalmic use.

PEDIATRIC USE:
Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and to exogenous corticosteroid effects than mature patients because of greater absorption due to a large skin surface area to body weight ratio.
HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasma Cortisol levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include a bulging fontanelle, headaches and bilateral papilledema.

USE DURING PREGNANCY AND IN NURSING WOMEN:
Since safety of topical corticosteroid use in pregnant women has not been established, drugs of this class should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively in large amounts or for prolonged periods of time in pregnant patients.
Since it is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable quantities in breast milk, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

OVERDOSE:
Symptoms: Excessive or prolonged use of topical corticosteroids can suppress pituitary-adrenal function, resulting in secondary adrenal insufficiency, and produce manifestations of hypercorticism, including Cushing's disease. A single overdose of gentamicin would not be expected to produce symptoms.
Excessive or prolonged use of topical antibiotics may lead to overgrowth of lesions by nonsusceptible organisms. Systemically, tolnaftate is pharmacologically inactive. Clioquinol rarely produces iodism.
Treatment:
Appropriate symptomatic treatment is indicated. Acute hypercorticoid symptoms are usually reversible. Treat electrolyte imbalance, if necessary. In case of chronic toxicity, slow withdrawal of corticosteroid is advised. If overgrowth by non-susceptible organisms occurs, stop treatment with Quadriderm Cream and institute appropriate therapy.

STORAGE:
Store below 25°C
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