College student Lewis decides to drive across the country to see Venna, a friend who doesn't know that Lewis is interested in her romantically. Unfortunately for his plans, Lewis gets saddled with his raucous-spirited older brother, Fuller, whose on-the-road pranks get the brothers and Venna sucked into a nightmare when a psychotic truckdriver takes offense.

The plot concerns Lewis Thomas, a young man who decides to go cross-country to pick up his high school sweetheart, Venna Wilcox, from college. On his way there, he bails his brother, Fuller Thomas, out of jail. Fuller, looking for a good time, decides to ride with Lewis. During their trip to pick up Venna, Fuller coaxes Lewis into playing a cruel joke, through their CB radio, on a truck driver, known only as 'Rusty Nail.' When the joke takes a deadly turn, Lewis, Venna, and Fuller find themselves being relentlessly stalked by the psychotic truck driver who is looking for more than an apology.

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