Item Description
 
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Redicres, Itravil 30mg 60 caps extended release -
Clobenzorex
 
 
dosage form
Each CAPSULE contains:Clobenzorex hydrochloride 30 mg
THERAPEUTIC INDICATIONS
Anorectics. Indicated for the treatment of people with a body
mass index (BMI) less than or greater than 30 kg / m2 and who have
not responded to a diet. Especially for those patients with
diabetes, heart disease and hypertension.
CLINICAL PHARMACOLOGY
The clobenzorex, after oral administration is well absorbed
from the gastrointestinal tract, reaches its maximum concentration
(Cmax) of one to one and a half after its administration and its
concentration varies from 8 to 47 ng / ml. It is excreted in the
urine, being one of the main metabolites amphetamine (15% of the
administered dose) and p-hidroxiclobenzorex (1.5 to 6% of the
administered dose).The clobenzorex is a sympathomimetic amine with
pharmacological activity similar to that of other drugs used to
treat obesity. It acts on the ventrolateral nucleus of the
hypothalamus, increasing the release of norepinephrine and
dopamine, and decreases its recapture in presynaptic nerve endings,
above, has the effect of increasing concentrations of
norepinephrine. Norepinephrine decreases appetite, activating the
receptor to-4 And ß1 in the hypothalamic nuclei.