Quadriderm Cream combines the anti-inflammatory, anti-pruritic and vasoconstrictive agent betamethasone valerate, the wide spectrum antibiotic gentamicin sulfate, the fungicidal agent tolnaftate and clioquinol, an antibacterial and antifungal agent.
Quadriderm Cream is indicated for the relief of the inflammatory manifestations of corticosteroid-responsive dermatoses when complicated by secondary infection caused by organisms sensitive to the components of this dermatologic preparation. Such disorders include inguinal dermatosis, eczematoid
dermatitis, contact dermatitis, microbial, dermatitis, follicular dermatitis, parakeratosis, anal pruritus, seborrheic eczema, intertrigo, seborrheic dermatitis, impetigo, zona occipital, lichenified inguinal dermatophytosis and tinea infections such as tinea pedis, tinea cruris and tinea corporis
DOSAGE AND ADMINISTRATION:
A thin film of Quadriderm Cream should be applied to cover completely the affected area two or three times daily, or as prescribed by the physician.
Frequency of application should be determined according to severity of the condition.
Duration of therapy should be determined by patient response. In cases of tinea pedis longer therapy (2-4 weeks) may be necessary.
Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and to exogenous corticosteroid effects than mature patients because of greater absorption due to a large skin surface area to body weight ratio.
HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasma Cortisol levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include a bulging fontanelle, headaches and bilateral papilledema.
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