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Ceremony held January 31, 2010.

Performances:

Lady Gaga and Elton John
Green Day with the cast of American Idiot
Beyoncé
Pink
The Black Eyed Peas
Lady Antebellum
Jamie Foxx, T-Pain, Slash and Doug E. Fresh
Zac Brown Band and Leon Russell
Taylor Swift, Stevie Nicks, Butch Walker
Tribute to Michael Jackson: Celine Dion, Usher, Carrie Underwood, Jennifer Hudson and Smokey Robinson
Bon Jovi and Jennifer Nettles
For the 2010 Haiti earthquake: Andrea Bocelli, Mary J. Blige and David Foster
Dave Matthews Band
Maxwell and Roberta Flack
Tribute to Les Paul: Jeff Beck and Imelda May
Drake, Lil Wayne, Eminem and Travis Barker

Appearances:

Simon Baker, Kristen Bell, Justin Bieber, Jeff Bridges, Jonas Brothers, Stephen Colbert, Alice Cooper, Sheryl Crow, Kaley Cuoco, Miley Cyrus, Mos Def, Plácido Domingo, Robert Downey Jr., Josh Duhamel, Wyclef Jean, Norah Jones, Juanes, Ke$ha, Miranda Lambert, John Legend, LL Cool J, Jennifer Lopez, Ricky Martin, Lea Michele, Chris O'Donnell, Katy Perry, Lionel Richie, Adam Sandler, Carlos Santana, Ryan Seacres, Seal, Ringo Starr, Quentin Tarantino, Keith Urban and more…