Cold sores (known
medically as herpes labialis) are caused by a virus, usually herpes
simplex virus type 1 (HSV-1). Cold sores, also called fever
blisters, usually occur on the lips or mouth (unlike canker sores,
which occur inside the mouth). Cold sores can be highly contagious
(they can spread to other people easily). Most people have been
infected with this virus, even if they have never had a cold
Acyclovir cream is
approved to treat recurrent cold sores in adults and adolescents
age 12 and older.
Acyclovir Cream Work?
As mentioned, cold
sores are caused by viruses -- specifically, the herpes simplex
viruses (HSV). Acyclovir cream is an antiviral medication that
helps the body fight the infection by preventing the virus from
It is important to
understand that once a person has been infected with these viruses,
they never go away. Rather, they remain inactive in certain nerve
cells of the body, waiting to become active again. In addition,
treatment with acyclovir cream does not prevent future outbreaks of
: Each 100g contains Acyclovir 5g
: For the treatment of herpes simplex virus infections of
the skin initial and recurrent genital herpes and herpes
Dosage and Administration :
- Apply to the
lesion or impending lesions 5 times daily at approximately
four-hourly intervals, as early as possible after the start of
- It is particularly
important to start treatment of recurrent episodes during the
prodromal period or when the lesions first appear. Treatment should
be continued for 5 days.
Considerations for people taking acyclovir cream include
The medication is to be used on the lips and skin of the face; it
is not meant to be ingested or to be used inside the mouth or
You should use disposable rubber, latex, or similar gloves to apply
acyclovir cream in order to prevent spreading the infection to
other parts of your body. Or, make sure to wash your hands
thoroughly after each application.
Mode of action :
- Acyclovir is an
antiviral agent which is highly active in vitro against Herpes
simplex virus (HSV) type I and II and Varicella zoster
mammalian host cells is low.
- Acyclovir is
phosphorylated after entry into herpes infected cells to the active
compound acyclovir triphosphate. The first step in the process is
dependent on the presence of the HSV coded thymidine kinase.
Acyclovir triphosphate acts as an inhibitor of and substrate for
the herpes specified DNA polymerase preventing further viral DNA
synthesis with affecting normal cellular processes.
: Hypersensitivity or chemical intolerance to the components
of the formulation.
Precautions and warning/and other informations :
- For cutaneous use
only. Do not use in the eye.
- It is not
teratogenic or carcinogenic nor does it affect fertility.
- No information is
available on the effects of acyclovir or on during human pregnancy
or on the fetus.
- No information is
available on levels of acyclovir in breast milk.
interactions : Acyclovir is not known to interact with any
effects / adverse reactions : Transient burning or stinging,
erythema or mild drying and flaking of skin have been reported in a
small propotion of patients.
condition : Store in a dry place and below 25C
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